Catalog Number - 68304-10P

Cogent RP C4 Butyl™ is a reversed-phase HPLC stationary phase designed for the separation of hydrophobic to moderately hydrophobic compounds. Manufactured using a traditional butyl (C4) bonded phase on ultra-high purity silica and fully double end capped, it provides excellent reproducibility, reliable peak shape, and balanced retention characteristics. As a USP L26 equivalent phase, it is commonly used as an alternative for compendial methods and for applications where lower hydrophobic retention than C8 or C18 phases is preferred.

68304-10P is an HPLC column packed with 3 µm RP C4 Butyl™ particles featuring a 100 Å pore size in a 4.6 mm ID x 100 mm format. This is one of the most popular Cogent C4 columns because it provides an excellent balance between chromatographic resolution and analysis time. The 100 mm length delivers greater peak capacity and resolving power than shorter 50 mm columns, while the 3 µm particles provide improved efficiency and sharper peaks compared to traditional 5 µm packings. Typical operating flow rates are approximately 0.8–1.5 mL/min depending on mobile phase composition, temperature, and system configuration.

This column is particularly well suited for hydrophobic and neutral compounds analyzed by reversed-phase HPLC. The C4 chemistry provides lower retention than C8 phases, making it advantageous when faster elution and shorter run times are desired without sacrificing chromatographic performance.

Key Benefits

• RP C4 Butyl™ stationary phase

• USP L26 equivalent chemistry

• Fully double end capped

• Traditional butyl (C4) bonded phase

• Ultra-high purity silica support

• 3 µm particle size

• Greater efficiency than 5 µm columns

• Improved peak capacity

• Excellent balance of speed and resolution

• Lower retention than C8 columns

Typical Applications

• USP L26 methods

• Reversed-phase HPLC

• Small molecule analysis

• Hydrophobic compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Method development

• Quality control testing

• Routine analytical methods

• Impurity profiling

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C4 Butyl™

• USP Classification: L26

• Chromatography Mode: Reversed Phase

• Bonded Phase: Butyl (C4)

• Endcapping: Fully Double End Capped

• Particle Size: 3 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Typical Flow Rate: 0.8–1.5 mL/min

• Brand: Cogent

Important Notes

• Suitable for conventional HPLC systems

• 3 µm particles provide higher efficiency and sharper peaks than comparable 5 µm columns

• Generates higher backpressure than larger particle columns

• The 100 mm length provides greater resolution and peak capacity than 50 mm columns

• Lower retention than comparable C8 stationary phases

• Well suited for hydrophobic and neutral compounds

• One of the most popular Cogent RP C4 Butyl™ column formats

• Commonly used as an alternative for USP L26 methods

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